Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis
نویسندگان
چکیده
منابع مشابه
DNA-damage response during mitosis induces whole-chromosome missegregation.
UNLABELLED Many cancers display both structural (s-CIN) and numerical (w-CIN) chromosomal instabilities. Defective chromosome segregation during mitosis has been shown to cause DNA damage that induces structural rearrangements of chromosomes (s-CIN). In contrast, whether DNA damage can disrupt mitotic processes to generate whole chromosomal instability (w-CIN) is unknown. Here, we show that act...
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Comment on: Macurek L, et al. Cell Cycle 2012; 12:251-62.
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53BP1 is a vertebrate BRCT motif protein, originally described as a direct interactor of p53, which has recently been shown to be implicated in the early response to DNA damage. Upon DNA damage, 53BP1 re-localises to discrete nuclear foci that are thought to represent sites of DNA lesions and becomes hyperphosphorylated. Several observations suggest that 53BP1 is a direct substrate for the atax...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2019
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2019.05.002